Development of Selective LDL Adsorbent and LDL Apheresis System: Immobilized Polyanion as LDL-Specific Adsorbent for LDL Apheresis System
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چکیده
منابع مشابه
LDL-Apheresis: Technical and Clinical Aspects
The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option. Today, there are five different LDL-apheresis systems available: cascade filtration or ...
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Epidemiologic studies and in vitro experiments indicate that low density lipoprotein (LDL) subtypes differ concerning their atherogenic potential. Small, dense LDL are more atherogenic than large, buoyant LDL. LDL apheresis is a potent therapeutic modality to lower elevated LDL-cholesterol. It is unknown whether such therapy induces a shift in the LDL subtype distribution. In this study we eval...
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Extracorporeal reduction of plasma low density lipoproteins (LDLs) by LDL apheresis was shown to attenuate the proatherogenic influences of LDL, such as impairment of vasodilation and increased monocyte adhesion to the endothelium. In 16 patients with familial hypercholesterolemia, we analyzed whether LDL apheresis by the heparin precipitation procedure affected the oxidative resistance of LDL....
متن کاملApplication of LDL-apheresis and immunoadsorption in kidney diseases.
Plasmapheresis is one of the methods of extracorporeal blood purification used for many decades for the treatment of different kidney and extrarenal diseases, mainly of autoimmunological nature. The main disadvantage of this method is the lack of selectivity and the risk of infections associated with plasma used for supplementation. Hence, the efforts are made to establish an alternative blood ...
متن کاملComplement profile and activation mechanisms by different LDL apheresis systems.
Extracorporeal removal of low-density lipoprotein (LDL) cholesterol by means of selective LDL apheresis is indicated in otherwise uncontrolled familial hypercholesterolemia. During blood-biomaterial interaction other constituents than the LDL particles are affected, including the complement system. We set up an ex vivo model in which human whole blood was passed through an LDL apheresis system ...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1990
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.18.2_173